M Brothers at Mayo Clinic is a full-service dining experience located in the heart of Jacksonville’s Mayo Clinic, welcoming both visitors and the public. Inspired by the legacy of excellence set forth by The Mayo Brothers, William and Charles Mayo, and continued by the culinary craftsmanship of Matthew and David Medure, M Brothers embodies a passion for quality, innovation, and exceptional hospitality.
With a dedication to high culinary standards, we bring thoughtfully curated dishes, impeccable presentation, and a stylish yet comfortable ambiance to every guest. Whether you're looking for an elegant dinner, a casual lunch, or a relaxing evening in our lounge, M Brothers is the perfect destination for an elevated dining experience.
a medure brothers culinary concept in collaboration with the mayo clinic jacksonville
WELCOME TO M BROTHERS AT MAYO
CULINARY PASSPORT DINNERS:
A GLOBAL TASTING ADVENTURE
Join us each month as Executive Chef Thomas Rivers and his team present a 4-course tasting menu inspired by global cuisine. Priced at $90 per person, with optional alcohol pairings available for $45 (tax and gratuity not included).
Reservations are available via OpenTable or by calling the restaurant directly.
Upcoming Culinary Passport Dinners:
April 19 – Florence
May 24 – Korea
June 21 – French Riviera
culinary passport reservations
hours + location
Dining Room Hours:
Lunch: Monday – Friday | 11:00 AM – 2:00 PM
Dinner: Monday – Saturday | 5:00 PM – 9:00 PM
Closed Sundays
m lounge Hours:
Monday – Friday | 11:00 AM – 9:00 PM
Saturday | 5:00 PM – 9:00 PM
happy hour:
MONDAY-FRIDAY IN THE LOUNGE | 4:00 PM – 6:00 PM
$8 House Wines
$4.50 Pints of Draft Beer
$6 Single Liquor Well Cocktails
location + Parking
4500 San Pablo Rd S, Jacksonville, FL 32224
Located in the Mayo Building Atrium
Parking – Available in the hospital parking garage.
Complimentary Valet – Available during dinner service.
Please see the hostess for validation.
